PTP1B inhibitors from Saussrurea lappa
1Department of Phytochemistry, China Pharmaceutical University, Nanjing 210038, China.
Journal of Asian Natural Products Research
|July 26, 2006
Summary
A new lignan glycoside was isolated from Saussurea lappa roots. Three anthraquinones from the extract demonstrated moderate inhibitory activity against human Protein Tyrosine Phosphatase 1B (hPTP1B).
Area of Science:
- Natural Product Chemistry
- Pharmacology
Background:
- Saussurea lappa is a plant used in traditional medicine.
- Phytochemical investigation of medicinal plants can yield novel bioactive compounds.
Purpose of the Study:
- To isolate and identify compounds from Saussurea lappa roots.
- To evaluate the bioactivity of isolated compounds against human Protein Tyrosine Phosphatase 1B (hPTP1B).
Main Methods:
- Extraction of Saussurea lappa roots using ethanol.
- Isolation and purification of compounds using chromatographic techniques.
- In vitro bioactivity assay against hPTP1B.
Main Results:
- A new lignan glycoside, 1,5-dihydroxypinoresinol-4'-O-beta-d-glucopyranoside, was identified.
- Twenty known compounds were also isolated and characterized.
- Three anthraquinones (aloe-emodin-8-O-beta-D-glucopyranoside, rhein-8-O-beta-D-glucopyranoside, and chrysophanol) exhibited moderate hPTP1B inhibitory activity.
Conclusions:
- Saussurea lappa roots are a source of diverse phytochemicals, including lignan glycosides and anthraquinones.
- The identified anthraquinones show potential as inhibitors of hPTP1B, suggesting therapeutic possibilities for metabolic disorders.
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