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Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
Published on: October 27, 2014
New taxanes from the seeds of Taxus mairei
1Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medicinal University, 336 Zhongshan East Road, 050017, Shijiazhuang, China.
Abstract:
Two new taxoid metabolites were isolated from the methanol extract of the Taxus mairei seeds. Their structures were established as 2alpha-hydroxy-9alpha,10beta,13alpha-triacetoxy-5alpha-cinnamoyloxytaxa-11-en-4beta,20-epoxide (1) and 2'-acetyl taxol (2) on the basis of spectral analysis.
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