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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Renal dysfunction and risk of ischemic stroke or TIA in patients with cardiovascular disease

Nira Koren-Morag1, Uri Goldbourt, David Tanne

  • 1Division of Epidemiology and Preventive Medicine, Sackler School of Medicine, Tel-Aviv University, Israel.

Neurology
|July 26, 2006
PubMed

Insights

Mild kidney dysfunction significantly increases ischemic stroke risk in patients with coronary heart disease. This highlights the need to manage renal impairment as a key factor in cardiovascular and stroke prevention.

Area of Science:

  • Nephrology
  • Cardiology
  • Neurology

Background:

  • Mild renal insufficiency is an emerging cardiovascular disease risk factor.
  • Limited data exist on the link between renal insufficiency and ischemic stroke risk.

Purpose of the Study:

  • To investigate the association between chronic kidney disease (CKD) and the risk of incident ischemic stroke or transient ischemic attack (TIA) in patients with coronary heart disease.

Main Methods:

  • A cohort of 6,685 patients with coronary heart disease was followed for incident ischemic stroke or TIA.
  • Glomerular filtration rate (GFR) was estimated using Cockroft-Gault and MDRD equations.
  • Chronic kidney disease (CKD) was defined as GFR ≤60 mL/minute/1.73 m2.

Main Results:

  • A quarter of the cohort had CKD.
  • CKD was associated with a 1.54-fold increased hazard ratio for ischemic stroke or TIA, after adjusting for conventional risk factors.
  • Each 1 SD decrease in GFR was linked to a higher risk of stroke.

Conclusions:

  • Mild renal dysfunction is linked to a higher risk of ischemic stroke or TIA in patients with atherothrombotic disease.
  • Patients with renal dysfunction should be considered a high-risk group for both cardiovascular disease and ischemic stroke.
Abstract

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