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Combined cardiovascular risk factors and outcome: NIPPON DATA80, 1980-1994

Yasuyuki Nakamura1, Takako Yamamoto, Tomonori Okamura

  • 1Cardiovascular Epidemiology, Kyoto Women's University, Japan. nakamury@kyoto-wu.ac.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|July 26, 2006
PubMed

Insights

Japanese men with multiple combined cardiovascular risk factors face significantly higher risks of coronary heart disease (CHD) and stroke mortality. Identifying and managing this high-risk group is crucial for improving health outcomes.

Area of Science:

  • Cardiovascular epidemiology
  • Public health
  • Preventive medicine

Background:

  • Combined cardiovascular risk factors pose a significant health concern.
  • Understanding their prognostic significance in diverse populations is essential.

Purpose of the Study:

  • To investigate the prognostic impact of combined cardiovascular risk factors on coronary heart disease (CHD) and stroke mortality in the Japanese population.
  • To analyze the relationship between a high-risk group defined by combined factors and mortality outcomes.

Main Methods:

  • Analysis of the NIPPON DATA80 database, following 4,144 men and 5,318 women for 14 years.
  • Defined risk factors: hypertension, hypercholesterolemia, hyperglycemia, and obesity.
  • Categorized subjects into risk groups (0, 1-2, and 3-4 combined risks).

Main Results:

  • Men in the high-risk group (3-4 combined factors) showed significantly elevated mortality.
  • Hazard ratios for CHD mortality were 8.04 and for stroke mortality were 5.06 compared to the low-risk group.
  • No statistically significant differences were observed in women, likely due to fewer events.

Conclusions:

  • A high-risk group with combined cardiovascular risk factors is a significant predictor of mortality in Japanese men.
  • This highlights the importance of managing multiple risk factors concurrently for preventive cardiovascular care in men.
Abstract

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