Related Experiment Video

Updated: Jul 26, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Pyoderma gangraenosum, a rare, but potentially fatal complication in paediatric oncology patients

P E Meissner1, U Jappe, C M Niemeyer

  • 1Department of Neonatology, Heidelberg University, Germany. peter.meissner@urz.uni-heidelberg.de

Klinische Padiatrie
|July 26, 2006
PubMed

Insights

Pyoderma gangrenosum (PG) is a rare but serious ulcerative skin condition in children, often linked to systemic diseases. Early diagnosis and multidisciplinary care are crucial for managing this challenging pediatric disorder.

Area of Science:

  • Dermatology
  • Pediatrics
  • Hematology

Background:

  • Pyoderma gangrenosum (PG) is a rare, chronic, ulcerative skin disorder.
  • It frequently co-occurs with systemic diseases (>50%), necessitating a multidisciplinary approach.
  • PG is uncommon in pediatric populations, posing diagnostic challenges.

Observation:

  • A 4-year-old boy with secondary myelodysplastic syndrome post-acute lymphoblastic leukemia treatment presented with severe lower lip ulcerative lesions.
  • The clinical presentation mimicked other ulcerative conditions, delaying diagnosis.

Findings:

  • The patient's condition was diagnosed as Pyoderma gangrenosum.
  • Literature review highlights diagnostic difficulties and treatment strategies for pediatric PG.
  • This case underscores the rarity of PG in childhood.

Implications:

  • Highlights the importance of considering PG in pediatric patients with unexplained ulcerative lesions, especially those with underlying systemic conditions.
  • Emphasizes the need for a multidisciplinary team in diagnosing and managing pediatric PG.
  • Contributes to understanding the diagnostic challenges and treatment landscape of this rare childhood skin disorder.

More Related Videos

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...