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[Bevacizumab. Progress in cancer therapy by antiangiogenesis]

Irene Krämer1, Hans-Peter Lipp

  • 1Apotheke des Klinikums der Johannes Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55131 Mainz.

Medizinische Monatsschrift Fur Pharmazeuten
|July 27, 2006
PubMed

Insights

Bevacizumab is a pioneering antiangiogenic monoclonal antibody used for advanced colorectal cancer, offering survival benefits. Its use is associated with side effects like hypertension and bleeding, prompting ongoing research into its optimal application and economic impact.

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Context:

  • Bevacizumab is the first humanized monoclonal antibody with antiangiogenic properties introduced into clinical oncology.
  • It is approved for treating advanced colorectal cancer due to demonstrated survival benefits.

Purpose:

  • To summarize the clinical application, benefits, and adverse events of bevacizumab in cancer therapy.
  • To highlight current discussions on optimizing combination therapies, exploring new indications, and evaluating pharmacoeconomic aspects of bevacizumab.

Summary:

  • Bevacizumab, a vascular endothelial growth factor (VEGF) antagonist, has shown significant survival benefits in advanced colorectal cancer.
  • Adverse events associated with bevacizumab include hypertension, proteinuria, impaired wound healing, bleeding, and thromboembolic events.
  • Current research focuses on optimizing combination therapies, identifying new indications, and assessing the pharmacoeconomic value of bevacizumab.

Impact:

  • Bevacizumab has established a new therapeutic class of antiangiogenic agents in oncology.
  • Understanding its side effect profile is crucial for safe and effective clinical use.
  • Further research into combination therapies and new indications may expand the utility of bevacizumab in various cancers.

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