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Published on: July 17, 2013
Gliosarcoma with liposarcomatous component, bone infiltration and extracranial growth
O C Borota1, D Scheie, B Bjerkhagen
1Department of Pathology, The University Hospital Rikshospitalet-Radiumhospitalet, Sognsvannsveien 20, 0027 Oslo, Norway. olivera.borota@rikshospitalet.no
Clinical Neuropathology
|July 27, 2006
Summary
Gliosarcoma, a rare malignant brain tumor, can exhibit diverse mesenchymal differentiation. This study details an unusual case with liposarcomatous features, expanding its known morphological spectrum.
Area of Science:
- Neuro-oncology
- Pathology
- Surgical Oncology
Background:
- Gliosarcoma is a rare, aggressive brain tumor comprising glial (glioblastoma) and mesenchymal elements.
- The mesenchymal component typically resembles fibrosarcoma but can show other differentiation patterns.
Observation:
- This report describes an unusual gliosarcoma case with extensive infiltration of the temporal bone and infratemporal fossa.
- Microscopic examination revealed alternating glioblastoma and fibrosarcoma areas, with focal osteosarcomatous and liposarcomatous differentiation.
Findings:
- The tumor demonstrated both typical glioblastoma and fibrosarcoma components, alongside rare osteosarcomatous and liposarcomatous differentiation.
- This case highlights gliosarcoma's potential for extensive extracranial invasion, including bone infiltration.
Implications:
- Gliosarcoma with transcranial penetration is rare but should be suspected in intracranial tumors with glioblastoma features and extracranial extension.
- The recognition of liposarcomatous differentiation broadens the understanding of gliosarcoma's diverse morphology and potential presentations.
