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Uterine development and endometrial programming.

F F Bartol1, A A Wiley, C A Bagnell

  • 1Department of Animal Sciences, Cellular & Molecular Biosciences Program, Auburn University, Auburn, Alabama 36849, USA. bartoff@auburn.edu

Society of Reproduction and Fertility Supplement
|July 27, 2006
PubMed
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Neonatal exposure to oestrogen (E) can epigenetically program the developing porcine uterus, altering gene expression and leading to hypoplastic adult uteri with reduced conceptus support. This highlights critical perinatal programming for uterine function.

Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Endocrinology

Background:

  • Uterine organogenesis involves complex structural and functional patterning, regulated by specific genes like Pax2, Lim1, Emx2, Hoxa cluster, Wnt, and Hedgehog.
  • Neonatal exposure to hormones like oestrogen (E) and relaxin (RLX) can influence uterine development, with RLX potentially interacting with oestrogen receptor-alpha (ER).

Purpose of the Study:

  • To investigate the effects of neonatal oestrogen administration on the developmental trajectory and functional programming of the porcine uterus.
  • To examine the impact of perinatal hormonal exposure on uterine gene expression patterns and subsequent responsiveness to conceptus signals.

Main Methods:

  • Administration of oestrogen to neonatal gilts for two weeks post-birth.
  • Analysis of temporospatial gene expression patterns (Hh, Wnt, Hoxa) in the uterine wall.

Related Experiment Videos

  • Assessment of adult uterine capacity for conceptus support, including growth response and luminal fluid protein accumulation.

    • Main Results:

    • Neonatal oestrogen exposure resulted in hypoplastic adult porcine uteri.
    • Altered endometrial gene expression and reduced responsiveness to periattachment conceptus signals were observed.
    • The data suggest perinatal hormonal exposure can epigenetically program the uterus, impacting its long-term functionality.

    Conclusions:

    • Neonatal hormonal programming, particularly via oestrogen, can significantly alter uterine development and function.
    • Epigenetic modifications during critical perinatal periods have lasting consequences on uterine capacity for reproduction.
    • Understanding these developmental pathways is crucial for reproductive success.