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Updated: Aug 6, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
Computer-aided spectrophotometric determination of multicomponent drugs
Abstract:
The conditions of least squares deconvolution by linear combination have been investigated in three-component systems. The significant effects of the main factors, the lack of significant interactions and the linear relationship of absorbance with the concentration of each component were established by using a 2(3) factorial experiment design and by evaluating the results with a three-way analysis of variance. The content of active ingredients of three-component injections was determined by means of computer-aided evaluation of UV-spectra in systems that fulfilled these conditions.
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