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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Determination of dextromethorphan and its metabolites in plasma by dual column liquid chromatography and fluorimetric

M Johansson1, C Svensson

  • 1Department of Research and Development, ACO Läkemedel AB, Box 3026, S-171 03 Solna, Sweden.

Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1988
PubMed

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The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte properties and...