Related Experiment Video
Updated: Aug 6, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Expressions for the fractional modification in different monocyclic enzyme cascade systems: analysis of their
R Varón1, E Valero, M Molina-Alarcón
1Departamento de Química Física, Escuela Politécnica Superior, Universidad de Castilla-La Mancha, Campus Universitario, E-02071 Albacete, Spain. ramon.varon@uclm.es
Abstract:
This paper presents the derivation, under a minimal set of assumptions, of a general expression for the steady-state fractional modification of an interconvertible protein involved in four different schemes of monocyclic enzyme cascade systems. From this general expression we derive, as particular cases, other, simpler expressions by applying additional assumptions and which have, therefore, a smaller range of validity. Some of these particular expressions coincide with those already obtained in previous contributions on individualised analyses. We discuss the relationships between the kinetic parameters and the concentrations needed for the fulfilment of the additional assumptions. The goodness of the analysis was tested by reference to the shape in the steady-state of the simulated time progress curves obtained by numerical integration.
Related Concept Videos
Multi-Step Reactions
Turnover Number and Catalytic Efficiency
Chymotrypsin is a pancreatic enzyme that breaks down proteins during digestion. The...
Amplifying Signals via Enzymatic Cascade
Partial Fractions
Substitution Rule Applied to Definite Integrals
Scaling
