Related Experiment Videos
Chronic electroconvulsive shock alters hypothermic response of B-HT 920 and SKF 38393 in rats
1Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
The Journal of Pharmacy and Pharmacology
|November 1, 1991
Abstract:
The hypothermic response of B-HT 920, a D2-dopamine agonist remained unaltered while that of apomorphine, a mixed D1-/D2-agonist was significantly reduced following chronic electro-convulsive shock (ECS) treatment. SKF 38393 (5 mg kg-1), a selective D1-agonist potentiated the hypothermic response of B-HT 920 in non-ECS-treated rats. The response of the combination was, however, attenuated following chronic ECS treatment. These observations suggested a reduction in D1-receptor density following chronic ECS treatment in rats.