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Updated: Aug 6, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
Published on: July 16, 2020
The native-state ensemble of proteins provides clues for folding, misfolding and function
Nunilo Cremades1, Javier Sancho, Ernesto Freire
1Department of Biochemistry and BIFI, University of Zaragoza, Zaragoza 50009, Spain.
Abstract:
The predominant equilibrium in proteins is not between native and unfolded states, it is between the native and multiple partially unfolded forms. Some of these partially unfolded forms can be energetically close to the native state and, therefore, have the potential to become appreciably populated. This could have an important role in protein function or misfolding diseases. The recent identification and characterization of the partially unfolded forms of apoflavodoxin furthers our understanding of their formation.
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