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Synthesis and HPLC assessment of N-nitrosoderivatives from six beta-adrenergic antagonists
M Mazzei1, E Sottofattori, A Balbi
1Istituto di Scienze Farmaceutiche Università di Genova, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|September 1, 1991
Abstract:
At first N-nitrosoderivatives from six beta-adrenergic antagonists of large consumption were prepared. Secondly the standard nitrosation reactions recommended by WHO were performed to get information about their possible in vivo production and the yields of N-nitrosoderivatives were evaluated by HPLC analyses. Pharmacological tests confirm the potential risk to man of the N-nitrosoderivatives studied.