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Updated: Aug 6, 2026

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
Published on: April 25, 2012
Psychopharmacology: clinical implications of brain neurochemistry
1Child and Adolescent Psychiatry and Behavioral Medicine, Medical College of Wisconsin and Children's Hospital of Wisconsin, 9000 West Wisconsin Avenue, MS 750, Milwaukee, WI 53201, USA. rscheffer@chw.org
Abstract:
There is an increasing prescription of psychotropic medications to youth. This use is accompanied by a developing, but lagging, evidence base for this use. These agents predominantly interact with regulatory neurotransmitters, which have known functions in the developing embryo. This article reviews major diagnostic categories in regards to the biological basis of the mainstays of pharmacology for each condition. Adverse events also are discussed in regards to these common psychopharmacological agents. There is growing evidence that the consequences of not treating serious psychiatric illnesses outweigh known risks of the medications. Prescription practices should endeavor to limit adverse consequences whenever possible.
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