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Alpha Interferon in AIDS-Related Progressive Multifocal Leukoencephalopathy
T Counihan1, N Venna, D Craven
1, Neurology Research, Warren 408, Massachusetts General Hospital, Fruit Street, Boston, MA, 02114.
Objective:
To determine the efficacy of recombinant interferon alpha in the treatment of progressive multifocal leukoencephalopathy associated with the acquired immunodeficiency syndrome (AIDS).
Design:
Open label, uncontrolled study.
Setting:
Neurological unit and clinical AIDS program, Boston City Hospital, Boston, MA.
Patients:
Four consecutive AIDS patients with pathologically confirmed progressive multifocal leukoencephalopathy.
Intervention:
Each patient received alpha interferon for 4-12 weeks in a dose of 5-10 million units daily, administered subcutaneously. In addition, two of the four were taking acyclovir 2400 mg/day orally over the same period.
Results:
None of the patients showed any clinical response to the therapy; the mean survival was 14 weeks. No adverse effects of the treatment were encountered.
Conclusions:
Despite anecdotal evidence that alpha interferon is effective in the treatment of progressive multifocal leukoencephalo pathy in non-AIDS patients, the experience of these patients suggests that the drug is of no benefit in AIDS-related PML.
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