Living donor liver transplantation to patients with hepatitis C virus cirrhosis

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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Yasuhiko Sugawara1, Masatoshi Makuuchi

  • 1Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. yasusuga-tky@umin.ac.jp

World Journal of Gastroenterology
|July 29, 2006
PubMed

Insights

Living donor liver transplantation (LDLT) offers a vital solution for hepatitis C virus (HCV) cirrhosis due to organ shortages. This review covers current strategies for managing HCV recurrence after LDLT, a critical factor impacting patient prognosis.

Area of Science:

  • Hepatology
  • Transplantation Medicine
  • Virology

Background:

  • Hepatitis C virus (HCV) cirrhosis is a leading cause of end-stage liver disease.
  • Cadaveric organ shortage limits liver transplantation options.
  • Living donor liver transplantation (LDLT) is a viable alternative for patients with HCV cirrhosis.

Purpose of the Study:

  • To review the clinical and therapeutic aspects of LDLT for HCV.
  • To discuss current antiviral strategies post-transplantation for HCV recurrence.
  • To highlight the importance of managing HCV in LDLT recipients.

Main Methods:

  • Literature review of recent clinical studies and therapeutic updates.
  • Analysis of outcomes in patients undergoing LDLT for HCV.
  • Synthesis of data on antiviral treatments and their efficacy.

Main Results:

  • HCV recurrence remains a significant challenge after LDLT.
  • Prognosis is often worse with HCV recurrence post-transplantation.
  • Antiviral strategies post-LDLT for HCV are evolving and under investigation.

Conclusions:

  • LDLT is a crucial option for HCV cirrhosis patients facing organ scarcity.
  • Effective management of HCV recurrence is paramount for successful LDLT outcomes.
  • Further research into optimal antiviral therapies is needed to improve long-term survival.

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