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[Central and peripheral neuromodulation of ejaculation. An updating contribution]
C Alberti1, P Sacchini, P Cortellini
1Cattedra e Scuola di Specializzazione di Urologia, Università degli Studi di Parma.
Summary
Recent research highlights novel neurotransmitters and neuroreceptors influencing seminal ejaculation. These include central amino acids, peptides, and peripheral neuropeptides, impacting ejaculation and drug interactions.
Area of Science:
- Neuroscience
- Pharmacology
- Reproductive Biology
Context:
- Seminal ejaculation involves complex central and peripheral neurochemical pathways.
- Emerging research identifies novel molecular players beyond traditional neurotransmitters.
Purpose:
- To review recent findings on neurotransmitters and neuroreceptors involved in seminal ejaculation.
- To discuss the roles of newly identified central and peripheral signaling molecules.
Summary:
- Central neurochemical systems involve amino acids, peptides, steroids, kinins, and prostaglandins, some glial-derived.
- Peripheral receptors include muscarinic, adrenergic, and neuropeptidic types (e.g., VIP, Neuropeptide Y, opioids).
- Pharmacological agents can modulate ejaculation at both central and peripheral sites.
Impact:
- Provides a comprehensive overview of the neurochemical basis of ejaculation.
- Highlights potential targets for pharmacological interventions related to ejaculatory dysfunction.
- Advances understanding of reproductive neurobiology and pharmacology.