Related Experiment Video
Updated: Aug 6, 2026
Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Novel technique for use of cyanoacrylate in Mohs surgery
Priya Zeikus1, Raymond Dufresne
1Department of Dermatology, Brown Medical School, Providence, Rhode Island 02903, USA.
Background:
Many Mohs procedures involve the handling and manipulating of thin, fragile skin tissue, particularly eyelid skin. After excision of such tissue, proper handling of the tissue becomes critical for tissue orientation and histologic processing.
Objective:
The authors present a novel way to handle thin, friable tissue after excision in Mohs surgery with the direct application of cyanoacrylate onto freshly excised tissue.
Methods:
Nonsterile generic cyanoacrylate can be applied along the epidermal surface edge to excised thin tissue sections before inking the margins, sectioning, and processing.
Conclusions:
The superglue increases tissue rigidity and provides for easier handling while staining and orienting the tissues. The added glue does not alter tissue integrity and shows minimal artifact upon histologic examination. This technique furthermore is inexpensive and adds little time to the Mohs procedure. Clinical photographs and histologic pictures are presented.
