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Updated: Jul 14, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Subcutaneous fat necrosis of the newborn with eosinophilic granules
Ani Tajirian1, Rustin Ross, Priya Zeikus
1Department of Dermatology, Brown Medical School, Rhode Island Hospital, RI 02903, USA. ani_tajirian@brown.edu
Abstract:
Subcutaneous fat necrosis (SFN) of the newborn is a variant of lobular panniculitis characterized by focal areas of fat necrosis and a granulomatous infiltrate composed of lymphocytes, histiocytes and multinucleated giant cells. Lipocytes and histiocytes contain needle-shaped clefts in a radial arrangement. Needle-shaped clefts may also be seen within the cytoplasm of multinucleated giant cells.(1-3) We present an unusual example of SFN showing multinucleated giant cells laced with eosinophilic granules. These eosinophilic granules are believed to be released from surrounding degranulating eosinophils.
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