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Part I. Dermatologic Manifestations in Patients with Kidney Disease
Amit Singal1, Jessica Liu2, Shawn E Cowper3
1Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Journal of the American Academy of Dermatology
|June 21, 2025
Summary
Dermatologic issues are common in chronic kidney disease (CKD) patients. This review covers the epidemiology, presentation, and management of skin conditions in CKD, aiding prompt diagnosis and treatment.
Area of Science:
- Nephrology
- Dermatology
Background:
- Chronic kidney disease (CKD) impacts global health, affecting 10% of the world's population.
- Dermatologic manifestations are frequent in CKD patients, posing diagnostic and therapeutic challenges.
- Lack of consensus guidelines complicates the management of skin conditions in CKD.
Purpose of the Study:
- To review common and unique dermatologic manifestations in patients with chronic kidney disease (CKD).
- To discuss the epidemiology, clinical presentation, histopathology, and management of these dermatoses.
- To provide essential information for timely diagnosis and management of skin conditions in CKD patients.
Main Methods:
- Literature review of dermatologic manifestations in CKD patients.
- Discussion of epidemiological data and clinical presentations.
- Overview of histopathological findings and treatment strategies.
Main Results:
- CKD is associated with a wide spectrum of dermatologic conditions.
- Key conditions discussed include pruritus, pigmentary changes, uremic frost, porphyria cutanea tarda, and acquired perforating disorders.
- Hair and nail changes are also significant manifestations in this population.
Conclusions:
- Prompt recognition of dermatologic disease is crucial for effective CKD patient management.
- Understanding these manifestations aids in avoiding complications and improving patient outcomes.
- This review serves as a foundational resource for clinicians managing CKD-related skin issues.
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