Related Experiment Video
Updated: Aug 6, 2026
06:01
Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
Published on: December 9, 2022
Carbamazepine-induced transient auditory pitch-perception deficit
Akihiko Tateno1, Ken Sawada, Ikuko Takahashi
1Department of Pediatrics, Sakura Hospital, Toho University School of Medicine, Chiba, Japan. tateno@med.toho-u.ac.jp
Pediatric Neurology
|August 1, 2006
Summary
Carbamazepine can cause temporary hearing problems, specifically pitch perception deficits, in patients with epilepsy or neuralgia. Awareness of this reversible side effect is crucial for patients starting this medication.
Area of Science:
- Neurology
- Ophthalmology
Background:
- Carbamazepine is an anticonvulsant and mood-stabilizing drug.
- Auditory disturbances are a known, though infrequent, side effect of carbamazepine therapy.
Observation:
- This report details six new cases of transient auditory disturbance, primarily pitch-perception deficit, associated with carbamazepine use.
- These cases involved patients with epilepsy and glossopharyngeal neuralgia.
Findings:
- Since 1993, a total of 32 cases of carbamazepine-induced transient pitch-perception deficit have been documented.
- The auditory disturbance can occur at therapeutic serum levels of carbamazepine.
Implications:
- Carbamazepine-induced hearing impairment may be more common than previously recognized.
- Educating patients about the potential for reversible hearing loss when initiating carbamazepine is essential for early detection and management.
Related Concept Videos
01:21Perceiving Loudness, Pitch, and Location
The human brain perceives pitch through two primary mechanisms reflected in place theory and frequency theory. Each mechanism describes how sound waves are interpreted as specific pitches by the brain, offering insights into the intricate processes of auditory perception.
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by identifying...
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by identifying...
01:29Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...