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Related Experiment Videos

Pontospinal transmitters and their distribution.

V K Reddy1, S J Fung, H Zhuo

  • 1Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman.

Progress in Brain Research
|January 1, 1991
PubMed
Summary
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The dorsolateral pontine tegmentum contains catecholaminergic neurons projecting to the spinal cord. Most of these neurons (75%) also contain enkephalin, suggesting complex neurotransmission.

Area of Science:

  • Neuroscience
  • Neuroanatomy
  • Cellular Neuroscience

Background:

  • The dorsolateral pontine tegmentum in cats hosts numerous catecholaminergic neurons.
  • Previous research identified diverse neurochemicals like acetylcholine, enkephalin, and serotonin in this region.

Purpose of the Study:

  • To map pontospinal neurons containing catecholamine, enkephalin, neuropeptide Y, and serotonin.
  • To investigate if enkephalin-positive neurons are also catecholaminergic.

Main Methods:

  • Utilized retrograde transport of horseradish peroxidase and immunocytochemistry.
  • Employed Fast Blue retrograde tracer combined with immunofluorescence histochemistry.

Main Results:

  • Pontospinal neurons were located in the locus coeruleus alpha, subcoeruleus, and Kölliker-Fuse nuclei.

Related Experiment Videos

  • The Kölliker-Fuse nucleus showed a higher concentration of these neurons.
  • 75% of pontospinal catecholaminergic neurons were found to contain enkephalin.

    • Conclusions:

    • Catecholaminergic neurons in the pontospinal pathway frequently co-express peptide neurotransmitters, notably enkephalin.
    • This suggests a complex neurochemical coding within these neuronal populations.