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Integrated-optic biosensor by electro-optically modulated surface plasmon resonance.

Tzyy-Jiann Wang¹, Wen-Shao Lin, Fu-Kuen Liu

¹Institute of Electro-optical Engineering, National Taipei University of Technology, Taipei 106, Taiwan. f10939@ntut.edu.tw

Biosensors & Bioelectronics

|August 1, 2006

Summary

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This study introduces an electro-optical modulation surface plasmon resonance (SPR) biosensor on lithium niobate for detecting beta-blocker concentration. The biosensor

Area of Science:

Integrated optics
Plasmonics
Biosensing

Background:

Surface plasmon resonance (SPR) biosensors are crucial for detecting analytes.
Existing SPR methods can be limited by sensitivity and response time.
Electro-optic materials offer potential for active modulation of optical properties.

Purpose of the Study:

To develop a novel integrated-optic SPR biosensor utilizing electro-optical modulation.
To demonstrate two distinct measurement methods: spectral and intensity.
To assess the biosensor's capability for detecting beta-blocker concentration in human serum albumin.

Main Methods:

Fabrication of an SPR biosensor on lithium niobate with integrated electrodes.
Application of voltage for electro-optical modulation of SPR characteristics.

Related Experiment Videos

Measurement of SPR wavelength shifts and output optical intensity changes.

Coating the gold film with human serum albumin for beta-blocker detection.

Main Results:

Electro-optical modulation effectively shifted the SPR wavelength and altered output intensity.
The slope of the measurand versus applied voltage correlated with analyte concentration.
The proposed method showed comparable results to conventional SPR techniques.
Waveguide width was identified as a factor influencing biosensor performance.

Conclusions:

The electro-optically modulated SPR biosensor provides a sensitive and tunable platform for analyte detection.
This integrated-optic approach offers advantages for real-time monitoring and miniaturization.
The method demonstrates potential for clinical diagnostics and pharmaceutical analysis.