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The effects of electroconvulsive shock on catecholamine function in the locus ceruleus and hippocampus
N Weiner1, M A Hossain, J M Masserano
1Department of Pharmacology, University of Colorado Health Sciences Center, Denver.
Journal of Neural Transmission. Supplementum
|January 1, 1991
Abstract:
Repeated electroconvulsive shock (ECS) treatment (once per day for 7 days) produced a significant increase in tyrosine hydroxylase activity, GTP-cyclohydrolase activity and tetrahydrobiopterin (BH4) levels in the locus ceruleus and hippocampus from 1 to 4 days after the last treatment. These changes may be responsible for, or contribute to, the antidepressant effect of ECS treatment.