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Smokers have severely disturbed peripheral micro-circulation.

M Midttun1, P Sejrsen, W P Paaske

  • 1Department of Geriatrics, Bispebjerg Hospital, Copenhagen, Denmark. mettemidttun@post.cybercity.dk

International Angiology : a Journal of the International Union of Angiology
|August 1, 2006
PubMed
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Smoking a single cigarette significantly reduces capillary blood flow in light smokers but not heavy smokers. Arteriovenous anastomoses (AVAs) blood flow is impaired in light smokers, while heavy smokers show no change, indicating disturbed peripheral microcirculation.

Area of Science:

  • Physiology
  • Vascular Biology
  • Nicotine Research

Background:

  • Peripheral microcirculation is crucial for tissue oxygenation.
  • Smoking is known to affect cardiovascular health.
  • Understanding the acute effects of smoking on microcirculation is important for assessing health risks.

Purpose of the Study:

  • To investigate the immediate impact of smoking one cigarette on capillary and arteriovenous anastomoses (AVAs) blood flow.
  • To compare these effects in light versus heavy chronic smokers.
  • To assess blood flow in specific microvascular beds: finger skin fold capillaries and thumb pulp AVAs.

Main Methods:

  • Employed the (133)Xenon local washout method for skin capillary blood flow measurement.
  • Utilized the heat washout method to assess blood flow in thumb pulp AVAs.

Related Experiment Videos

  • Measured blood flow rates in 5 light and 5 heavy smokers before, during, and after smoking a single cigarette.

    • Main Results:

    • Capillary blood flow decreased significantly during smoking in both light and heavy smokers.
    • In light smokers, AVA blood flow reduced by 2.6-fold during smoking, returning to baseline post-smoking.
    • Heavy smokers exhibited unchanged AVA blood flow during and after smoking, contrasting with light smokers.
    • Baseline capillary blood flow was higher in both smoker groups compared to non-smokers.

    Conclusions:

    • Smoking a single cigarette causes significant, albeit transient, disturbances in peripheral microcirculation.
    • Heavy smokers display altered responses in AVAs compared to light smokers, suggesting adaptive changes or severe impairment.
    • These findings highlight the detrimental impact of smoking on microvascular function and support the notion of severely disturbed peripheral microcirculation in smokers.