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Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
Published on: March 30, 2017
[A new breath actuated dry powder inhaler (Auto-Jethaler)]
J O Steiss1, M Heckmann, B Jödicke
1Zentrum für Kinderheilkunde und Jugendmedizin der Universität Giessen. Jens-Oliver.Steiss@paediat.med.uni-giessen.de
Klinische Padiatrie
|August 1, 2006
Summary
The Auto-Jethaler, a new breath-actuated dry powder inhaler, is easy for children over 3 to handle. Patients with respiratory conditions achieved adequate inspiratory flow rates with the device.
Area of Science:
- Respiratory Medicine
- Pediatric Pulmonology
- Device Engineering
Context:
- Dry powder inhalers (DPIs) are crucial for respiratory disease management.
- The Auto-Jethaler is a novel breath-actuated DPI designed for improved usability.
- Assessing device handling and performance in pediatric populations is essential.
Purpose:
- To evaluate the handling and inspiratory flow characteristics of the Auto-Jethaler in patients with respiratory conditions.
- To determine if patients can achieve adequate inspiratory flow rates through the Auto-Jethaler.
- To assess the device's suitability for drug delivery in children.
Summary:
- 75 patients (3-34 years) with asthma, cystic fibrosis, or primary ciliary dysfunction participated.
- Peak Inspiratory Flow (PIF) was measured with and without the Auto-Jethaler.
- All patients successfully operated the Auto-Jethaler, achieving the critical inspiratory flow of 40 L/min.
Impact:
- The Auto-Jethaler demonstrates ease of use and effective inspiratory flow generation in a pediatric cohort.
- Findings suggest the Auto-Jethaler is a suitable device for medication delivery in children over 3 years old.
- Successful use is contingent on patients understanding the required inspiratory maneuver.
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