Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rabies: epidemiological tendencies and control tools.

N Tordo1, C Bahloul, Y Jacob

  • 1Unit Antiviral Strategies, Virology Department, Institut Pasteur, Paris, France. ntordo@pasteur.fr

Developments in Biologicals
|August 2, 2006
PubMed
Summary

Rabies encephalitis causes 50,000 deaths annually. Developing broader spectrum vaccines, like DNA-based immunization with chimeric G proteins, is crucial to combat diverse lyssaviruses, especially those from bats.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is Quality of Patient-Surgeon Relationship associated with consultation duration in hand surgery?

Hand surgery & rehabilitation·2026
Same author

Supramolecular microgels for Pickering emulsion stabilization in the limited coalescence regime: The key role of microgel structure.

Journal of colloid and interface science·2026
Same author

[Joint Thesis Award 2024 of the Société française de virologie and ANRS | Maladies infectieuses émergentes].

Virologie (Montrouge, France)·2025
Same author

Skull Vibration Induced afternystagmus: A new clinical indicator of superior canal dehiscence.

European annals of otorhinolaryngology, head and neck diseases·2025
Same author

[Joint Thesis Award 2023 of the Société française de virologie and ANRS | Maladies infectieuses émergentes].

Virologie (Montrouge, France)·2024
Same author

Relationships between depression, anxiety, and motivation in the real-world: Effects of physical activity and screentime.

medRxiv : the preprint server for health sciences·2024

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Rabies encephalitis, caused by lyssaviruses, results in 50,000 human deaths yearly.
  • Lyssaviruses exhibit genetic diversity across seven genotypes (GT) within two phylogroups (PG), with ongoing evolution due to bat-borne strains.
  • Bat rabies is a growing public and animal health concern, as current vaccines offer limited protection against diverse lyssavirus genotypes.

Purpose of the Study:

  • To address the limitations of current rabies vaccines against diverse lyssavirus genotypes.
  • To explore novel vaccine strategies for broadening protection against bat-borne lyssaviruses.
  • To investigate the potential of DNA-based immunization and chimeric G proteins for enhanced rabies vaccine efficacy.

Main Methods:

  • Phylogenetic analysis to understand lyssavirus evolution and host-switching events.

Related Experiment Videos

  • Investigation of functional differences between lyssavirus genotypes (neurotropism, immunogenicity).
  • Development and evaluation of DNA-based immunization using plasmids expressing chimeric G proteins.

    • Main Results:

    • Phylogenetic studies suggest lyssaviruses evolved in bats before spreading to carnivores.
    • Chimeric G protein-based DNA immunization effectively elicits a complete immune response.
    • This approach broadens the protective spectrum of vaccines against various lyssavirus genotypes.

    Conclusions:

    • Current rabies vaccines are insufficient against the growing threat of diverse bat-borne lyssaviruses.
    • DNA-based immunization with chimeric G proteins offers a promising strategy to broaden vaccine efficacy.
    • The lyssavirus G protein can be engineered for multivalent vaccines against zoonotic diseases.