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[Clastogenic, aneugenic, pro- and antioxidant properties of some neurotropic preparations]
Abstract:
In experimental and clinical investigations, assessment was made of mutagenous, antimutagenous, pro- and antiradical activity of some neurotropic preparations--cerebrolysin, encephabol (pyritinol), nootropil (piracetam), actovegin and cavinton (vinpocetine). In chemical, fermentative and cellular model systems, cerebrolysin inhibited generation of superoxide anion-radical, nitrogen monoxide and final products of degradation of fatty acids. Other preparations showed both anti- and prooxidant effect. The most pronounced anticlastogenic activity during expriments on C. capillaries had a cerebrolysin. Encephabol had the most prooxidant effect and low anticlastogenic activity. The ability of such preparations as ceredrolysin and encephabol to decrease erythrocyte high level with micronuclei in peripheric blood of patients with infantile cerebral palsy (spastic diplegia) was clinically investigated. The modifying effect of preparations was not univalent: it was cerebrolysin that decreased intensivity of aneu- and clastogenesis in patients in a greater degree than encephabol. A protective effect of these preparations was pronounced on the 10th day in group of the boys, and on the 20th day in the group of the girls.
Insights
Cerebrolysin demonstrated significant antimutagenic and antiradical properties, effectively reducing oxidative stress and clastogenesis in both experimental models and clinical settings for infantile cerebral palsy. Other neurotropic drugs exhibited varied antioxidant and prooxidant effects.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Neurotropic preparations are used in treating neurological disorders.
- Understanding their mutagenic, antimutagenic, and radical scavenging activities is crucial.
- Oxidative stress plays a role in neurological conditions.
Purpose of the Study:
- To assess the mutagenous, antimutagenous, prooxidant, and antiradical activities of five neurotropic drugs.
- To investigate the clinical efficacy of cerebrolysin and encephabol in reducing micronuclei in patients with infantile cerebral palsy.
Main Methods:
- Chemical, fermentative, and cellular model systems were used for in vitro assessments.
- Experiments on C. capillaries evaluated anticlastogenic activity.
- Clinical study involved patients with infantile cerebral palsy (spastic diplegia).
Main Results:
- Cerebrolysin inhibited superoxide anion-radical and nitrogen monoxide generation.
- Cerebrolysin exhibited the most potent anticlastogenic activity.
- Cerebrolysin and encephabol reduced erythrocyte micronuclei levels in patients, with cerebrolysin showing greater efficacy.
Conclusions:
- Cerebrolysin possesses significant antiradical and antimutagenic properties.
- The neurotropic preparations have varied effects, with cerebrolysin being the most effective in reducing clastogenesis.
- Clinical application showed cerebrolysin's potential in managing oxidative stress-related genetic damage in infantile cerebral palsy.
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