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Seminal plasma magnesium and premature ejaculation: a case-control study.

Mehdi Aloosh1, Mohammad Hassani, Mohammadreza Nikoobakht

  • 1Urology Research Center of Sina Hospital, Tehran University of Medical Sciences and Health Services, Iran. MD_aloosh@hotmail.com

BJU International
|August 2, 2006
PubMed
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Premature ejaculation (PE) is linked to lower seminal plasma magnesium levels. Further research is needed to understand the underlying causes of this association in men.

Area of Science:

  • Urology
  • Andrology
  • Biochemistry

Background:

  • Premature ejaculation (PE) is a common male sexual dysfunction.
  • Magnesium is an essential mineral involved in numerous physiological processes.

Purpose of the Study:

  • To investigate the association between premature ejaculation (PE) and serum and seminal plasma magnesium levels.
  • To explore the potential role of magnesium in the pathophysiology of PE.

Main Methods:

  • A case-control study involving 38 men was conducted.
  • 19 men with PE (intravaginal ejaculatory latency time <1 min) and 19 controls with normal IELT were evaluated.
  • Serum and seminal plasma magnesium levels were measured using atomic absorption spectrophotometry after excluding other disorders.

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Main Results:

  • Seminal plasma magnesium levels were significantly lower in men with PE compared to controls (P < 0.001).
  • No significant association was found between serum magnesium levels and PE (P = 0.597).

Conclusions:

  • Lower seminal plasma magnesium levels are significantly associated with premature ejaculation (PE).
  • The precise pathological mechanisms linking seminal plasma magnesium to PE warrant further investigation.