Related Experiment Video
Updated: Aug 6, 2026
12:18
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Mild cognitive impairment should be considered for DSM-V
Ronald C Petersen1, John O'Brien
1Mayo Clinic College of Medicine, Department of Neurology, Rochester, MN 55905, USA. peter8@mayo.edu
Journal of Geriatric Psychiatry and Neurology
|August 2, 2006
Summary
Mild cognitive impairment (MCI) is a distinct condition, not normal aging or dementia. Evidence supports its inclusion in the DSM-V, especially the amnestic subtype, a likely Alzheimer's disease precursor.
Area of Science:
- Neurology
- Psychiatry
- Gerontology
Background:
- Mild cognitive impairment (MCI) is a critical transitional phase between normal aging and dementia.
- It is a subject of significant clinical and research interest.
- Distinguishing MCI from normal aging and early dementia is crucial for timely intervention.
Purpose of the Study:
- To advocate for the inclusion of mild cognitive impairment in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V).
- To present evidence supporting MCI as a distinct diagnostic entity.
- To highlight the amnestic subtype as a potential precursor to Alzheimer's disease.
Main Methods:
- Review and synthesis of clinical data.
- Analysis of outcome studies.
- Examination of epidemiological findings.
- Evaluation of neuroimaging and pathophysiological evidence.
Main Results:
- Mild cognitive impairment is demonstrably distinct from normal aging and clinically probable Alzheimer's disease.
- The amnestic subtype of MCI shows strong links to Alzheimer's disease pathology.
- MCI meets inclusion criteria for DSM-V classification, potentially more so than some existing diagnoses.
Conclusions:
- Mild cognitive impairment warrants recognition as a separate construct in psychiatric and neurological classifications.
- Inclusion in the DSM-V would facilitate standardized diagnosis and research.
- Further research is needed to fully elucidate the uncertainties surrounding MCI.
More Related Videos
Related Concept Videos
01:22Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
01:30Dementia
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
The progression of dementia is generally gradual.
01:29Intellectual Disability
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
01:30Cognitive Development During Adulthood
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
01:27Diagnostic and Statistical Manual of Mental Disorders (DSM)
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
01:26Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...