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Updated: Aug 6, 2026
In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Synthesis, crystal structure, and DNA-binding study on the
Kewei Lei1, Weisheng Liu, Xiaofeng Huang
1Department of Chemistry and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China.
Abstract:
A 2,2'-[2,3-naphthylenebis(oxy)]-bis(N,N-diisopropyl(acetamide)) ligand (L) and its Gd(III) complex have been prepared and characterized. The crystal and molecular structure of the complex was determined by single-crystal X-ray diffraction. The interactions of complex with calf thymus DNA were investigated by UV-vis, fluorescence and viscosity measurements. Experimental results indicated that the complex can bind to DNA by intercalation modes. Its intrinsic binding constant is 1.03 x 10(6) M(-1).
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