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Clinical inquiries. Which medications can be split without compromising efficacy and safety?
John Noviasky1, Vincent Lo, Diane D Luft
1St. Elizabeth Medical Center, Utica, NY, USA.
Abstract:
Split tablets of lisinopril are as effective as whole tablets of the same dose for hypertension (strength of recommendation [SOR]: B, based on small randomized crossover study). Similarly, split tablets of atorvastatin, lovastatin, and simvastatin are no less effective for lowering cholesterol (SOR: B, based on retrospective cohort studies). Extended-release, enteric-coated, or tablets that cannot be split accurately are not appropriate for splitting (SOR: C, based on observational studies); the accuracy of splitting also depends on device used and user skill (SOR: C, based on observational study).
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