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Updated: Aug 6, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
Monitoring vascular health beyond blood pressure
1Rasmussen Center for Cardiovascular Disease Prevention, Medical School, University of Minnesota, 420 Delaware Street SE, Minneapolis, 55455, USA. cohnx001@umn.edu
Insights
Vascular changes begin in childhood and are linked to cardiovascular risk factors. Measuring arterial stiffness can identify at-risk individuals early, aiding in the prevention of hypertension and vascular disease progression.
Area of Science:
- Cardiovascular medicine
- Vascular biology
- Preventive cardiology
Background:
- Vascular changes like atherosclerosis start asymptomatically in childhood.
- Cardiovascular risk factors track from childhood to adulthood, predicting adult cardiovascular disease.
- Arterial stiffness evaluation may identify at-risk individuals before hypertension develops.
Purpose of the Study:
- To explore the role of arterial stiffness measurement in early detection and management of vascular disease.
- To assess the potential of arterial stiffness as a supplement to blood pressure measurement in clinical practice.
Main Methods:
- Utilizing measurements of arterial stiffness and its predictors.
- Analyzing the predictive value of arterial stiffness for cardiovascular disease risk.
- Observing current research and clinical applications of arterial stiffness measurements.
Main Results:
- Arterial stiffness measurements are currently used in research and cardiovascular risk prediction clinics.
- Arterial stiffness can identify individuals at risk before blood pressure is elevated.
- Arterial stiffness monitoring can aid in preventing hypertension and vascular disease progression.
Conclusions:
- Arterial stiffness measurement is a valuable tool for detecting early vascular disease.
- It can serve as a supplement to blood pressure measurement in routine patient assessment.
- Wider availability of techniques could integrate arterial stiffness assessment into daily clinical practice for proactive cardiovascular care.
Abstract:
It is well recognized that vascular changes, including atherosclerosis, begin early in life as a silent, asymptomatic disease process and are associated with cardiovascular (CV) risk factors. Importantly, CV risk factors persist or track from childhood to adulthood and are predictive of CV disease risk in adults. Evaluation of arterial stiffness and its predictors may help identify asymptomatic individuals at risk, before blood pressure is elevated above an "arbitrary" level that we currently identify as hypertension. Currently, measurements of arterial stiffness are being used in the research setting and also as part of cardiovascular risk prediction clinics. As the various techniques become more widely available, it is conceivable that the measurement of arterial stiffness could become an important part of the routine assessment of patients in daily practice, as a supplement to blood pressure measurement. Measurement of arterial stiffness will not only be helpful in the detection of early vascular disease but also will be a tool in the follow-up monitoring of strategies aimed at preventing hypertension or reducing further progression of vascular disease before blood pressure elevation can be detected.
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