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Related Experiment Videos

Brassicaceae contain nortropane alkaloids.

Andrea Brock1, Tobias Herzfeld, Reinhard Paschke

  • 1Institute of Pharmaceutical Biology and Pharmacology, Faculty of Pharmacy, Martin Luther University Halle-Wittenberg, Hoher Weg 8, D-06120-Halle, Germany.

Phytochemistry
|August 4, 2006
PubMed
Summary
This summary is machine-generated.

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Tropane alkaloids, including cochlearine and calystegines, were identified in all Cochlearia species and many other Brassicaceae plants. This suggests these alkaloids are common secondary compounds in the Brassicaceae family.

Area of Science:

  • Plant biochemistry
  • Phytochemistry
  • Natural product chemistry

Background:

  • Cochlearine, a tropine ester, was previously found in Cochlearia officinalis (Brassicaceae).
  • Tropane alkaloids are characteristic of the Solanaceae family.
  • Calystegines are nortropane alkaloids derived from pseudotropine.

Purpose of the Study:

  • To screen Cochlearia species for tropane alkaloids and calystegines.
  • To investigate the presence of calystegines in other Brassicaceae species.
  • To determine if tropane alkaloid biosynthesis is widespread in Brassicaceae.

Main Methods:

  • Phytochemical screening of ten Cochlearia species.
  • Analysis of 43 Brassicaceae species for calystegines.
  • Identification and structural analysis of alkaloids.

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Main Results:

  • Cochlearine, tropine, and pseudotropine were found in all ten Cochlearia species.
  • Calystegines were identified in all Cochlearia species, accumulating up to 0.5% dry mass in leaves.
  • Calystegines were detected in 18 out of 43 analyzed Brassicaceae species across major lineages.
  • Calystegines were found even in Aethionema, a basal species of Brassicaceae.

Conclusions:

  • Tropane alkaloids and their derivatives are present in all investigated Cochlearia species.
  • Calystegines are widely distributed within the Brassicaceae family.
  • The presence of calystegines in basal and diverse Brassicaceae lineages suggests tropane alkaloids are a typical class of secondary metabolites for this family.