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Mumps vaccine virus strains and aseptic meningitis

Marie-Claude Bonnet1, Anil Dutta, Clement Weinberger

  • 1Sanofi Pasteur, Medical Affairs International, 2, Avenue Pont Pasteur, 69007 Lyon, France. marie-claude.bonnet@sanofipasteur.com

Vaccine
|August 4, 2006
PubMed

Insights

Live mumps vaccines are safe and effective for national immunization programs, offering a favorable risk-benefit ratio. Despite rare cases of aseptic meningitis, widespread use demonstrates their overall benefit.

Area of Science:

  • Vaccinology
  • Public Health
  • Epidemiology

Background:

  • Mumps immunization is crucial for national health strategies, often combined with measles vaccines.
  • Concerns exist regarding the safety of different mumps vaccine strains and their cost-effectiveness.

Purpose of the Study:

  • To evaluate data on mumps vaccine strains (Urabe and others) and aseptic meningitis.
  • To review comparative immunogenicity, efficacy, and cost of widely used mumps vaccines.

Main Methods:

  • Review of available data on vaccine-associated aseptic meningitis.
  • Analysis of controlled clinical trials and field evaluations for immunogenicity and efficacy.
  • Examination of vaccine cost in relation to national immunization programs.

Main Results:

  • Extensive global experience confirms the favorable risk-benefit profile of live mumps vaccines.
  • The Urabe strain and other mumps vaccine strains are associated with rare instances of aseptic meningitis.

Conclusions:

  • Live mumps vaccines are highly favorable for vaccination programs.
  • Despite occasional aseptic meningitis, the benefits of mumps vaccination outweigh the risks.

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