Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bullous paraneoplastic acrokeratosis].

A Schoeffler1, V Sagot, A Marzin

  • 1Service de Dermatologie, Centre Hospitalier de Valence.

Annales De Dermatologie Et De Venereologie
|August 4, 2006
PubMed
Summary

This study details a rare case of Bazex's syndrome (acrokeratosis paraneoplastica) presenting with bullous lesions. Treatment of the underlying cancer led to the resolution of these unusual acral bullae.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026
Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36  TeV with the ATLAS Detector at the LHC.

Physical review letters·2025

Area of Science:

  • Dermatology
  • Oncology
  • Immunology

Background:

  • Bazex's syndrome, or acrokeratosis paraneoplastica, is a rare paraneoplastic condition.
  • Bullous lesions on the extremities are an uncommon manifestation of Bazex's syndrome.

Observation:

  • A 65-year-old male with a history of alcohol and smoking presented with acrokeratosis paraneoplastica and a cervical lymph node mass, later diagnosed as piriform sinus epidermoid carcinoma.
  • The patient developed worsening acral keratotic lesions, accompanied by painful, hemorrhagic bullous lesions on his feet and toes.
  • Histopathology revealed subepidermal blisters with eosinophils, and direct immunofluorescence showed C3, IgA, and IgM deposits.

Findings:

  • The patient exhibited blood eosinophilia and elevated IgE levels.
  • Treatment with radiation and chemotherapy for the epidermoid carcinoma resulted in the healing of bullous lesions and regression of keratotic lesions.

Related Experiment Videos

  • The bullous lesions mimicked autoimmune bullous diseases, suggesting an immunological basis.

    • Implications:

    • This case highlights that bullous lesions, though rare, can be an early sign of Bazex's syndrome.
    • The findings suggest an immunological reaction involving the dermal-epidermal junction and eosinophils in the pathogenesis of these bullous lesions.
    • Successful cancer treatment led to the resolution of paraneoplastic dermatological manifestations.