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[Activity of acid aspartic proteinase Candida strains isolated from palatine tonsils]

A Rózga1, A Jaskółowska, P Kurnatowski

  • 1Katedra Biologii i Parazytologii Lekarskiej AM, 90-436 Lódź, ul. Al. Kościuszki 85.

Wiadomosci Parazytologiczne
|August 5, 2006
PubMed

Insights

Candida strains from tonsil homogenates exhibit significant proteolytic activity. Infected tonsils showed reduced T-lymphocyte rosette formation compared to uninfected ones.

Area of Science:

  • Microbiology
  • Immunology

Background:

  • Palatine tonsils are a common site for Candida colonization.
  • Tonsillectomy patients may have altered oral microbial environments.

Purpose of the Study:

  • To evaluate the asparagine protease activity of Candida strains isolated from palatine tonsils.
  • To assess the relationship between Candida infection and T-lymphocyte rosette formation in tonsil tissue.

Main Methods:

  • Isolation and identification of Candida strains from palatine tonsil homogenates.
  • Assay of acidous asparagine protease activity by measuring the zone of proteolysis.
  • Quantification of E-rosette forming T-lymphocytes in tonsil tissue.

Main Results:

  • Candida albicans and Candida tropicalis were the most frequently isolated species.
  • Over 60% of Candida strains displayed high or very high proteolytic activity.
  • Tonsils infected with Candida showed significantly lower T-lymphocyte rosette formation compared to uninfected tonsils.

Conclusions:

  • Candida strains from palatine tonsils possess significant proteolytic capabilities.
  • Candida infection in palatine tonsils is associated with a diminished T-lymphocyte immune response.

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