Related Experiment Video
Updated: Aug 6, 2026

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
[Genetics in rheumatoid arthritis (RA)]
Jadwiga Skretkowicz1, K Skretkowicz-Szarmach
1Uniwersytet Medyczny w Lodzi, Zakład Farmakogenetyki. jskretkowicz@pharm.am.lodz.pl
Summary
Genetic factors significantly contribute to rheumatoid arthritis (RA), a chronic autoimmune disease. This study explores various genetic phenomena, including MHC antigens and gene polymorphisms, involved in RA
Area of Science:
- Immunology
- Genetics
- Rheumatology
Context:
- Rheumatoid arthritis (RA) is a complex autoimmune disorder.
- Both genetic and environmental factors influence RA pathogenesis.
- Understanding the genetic underpinnings of RA is crucial for developing targeted therapies.
Purpose:
- To investigate the role of various genetic factors in the etiopathogenesis of rheumatoid arthritis.
- To analyze major histocompatibility complex (MHC) antigens, whole genome scan linkage data, and gene polymorphisms in RA.
- To elucidate the polygenic nature of RA.
Summary:
- This study examines multiple genetic phenomena implicated in rheumatoid arthritis.
- Key areas of investigation include major histocompatibility complex antigens, results from whole genome linkage analysis, and polymorphisms in genes encoding receptors, adhesion molecules, and cytokines.
- The findings highlight the significant role of a complex genetic background involving multiple genes in RA development.
Impact:
- Provides a comprehensive overview of genetic factors contributing to rheumatoid arthritis.
- Highlights the importance of a polygenic model for understanding RA.
- Informs future research directions for genetic association studies and therapeutic target identification in RA.
Related Concept Videos
Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
The JAK-STAT Signaling Pathway
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Human Genetics
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...