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Updated: Aug 6, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone
Vu Ma1, Anthony W Bannon, Jamie Baumgartner
1Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. vma@amgen.com
Abstract:
Melanin-concentrating hormone (MCH) is a cyclic 19 amino acid orexigenic neuropeptide. The action of MCH on feeding is thought to involve the activation of its respective G protein-coupled receptor MCH-R1. Consequently, antagonists that block MCH regulated MCH-R1 activity may provide a viable approach to the treatment of diet-induced obesity. This communication reports the discovery of a novel MCH-R1 receptor antagonist, the biarylether 7, identified through high throughput screening. The solid-phase synthesis and structure-activity relationship of related analogs is described.
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