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Related Experiment Videos

Clues to VIP function from knockout mice.

S A Hamidi1, A M Szema, S Lyubsky

  • 1Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794-8172, USA. sami.i.said@stonybrook.edu

Annals of the New York Academy of Sciences
|August 5, 2006
PubMed
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Vasoactive intestinal polypeptide (VIP) knockout mice exhibit increased airway hyperresponsiveness and inflammation, suggesting a role in asthma. These mice also showed higher mortality from endotoxemia and signs of pulmonary hypertension.

Area of Science:

  • Immunology
  • Pulmonology
  • Pharmacology

Background:

  • Vasoactive intestinal polypeptide (VIP) is a neuropeptide with known immunomodulatory and anti-inflammatory properties.
  • The role of VIP in respiratory and circulatory diseases remains incompletely understood.

Purpose of the Study:

  • To investigate the impact of VIP gene deletion on airway reactivity, inflammation, endotoxemia mortality, and pulmonary circulation.
  • To elucidate the physiological functions of VIP in the context of asthma models and septic shock.

Main Methods:

  • Utilized vasoactive intestinal polypeptide (VIP) knockout (KO) mice.
  • Assessed airway reactivity using methacholine challenge.
  • Evaluated airway inflammation through histological examination.
  • Determined mortality rates following endotoxemia induction.

Related Experiment Videos

  • Examined indicators of pulmonary hypertension.

    • Main Results:

    • VIP KO mice displayed significant airway hyperresponsiveness to methacholine.
    • Peribronchial and perivascular inflammation were observed in VIP KO mice.
    • VIP KO mice exhibited increased susceptibility to mortality from endotoxemia.
    • Evidence suggestive of pulmonary hypertension was present in VIP KO mice.

    Conclusions:

    • Deletion of the VIP gene exacerbates airway hyperresponsiveness and inflammation, indicating a protective role for VIP in asthma-like conditions.
    • VIP deficiency increases mortality in a model of septic shock.
    • VIP plays a crucial role in maintaining pulmonary vascular homeostasis and preventing pulmonary hypertension.