Related Experiment Video
Updated: Jul 28, 2026
07:11
Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques
Published on: April 22, 2010
PACAP receptor (PAC1-R) expression in rat and rhesus monkey thymus.
N Tokuda1, Y Arudchelvan, T Sawada
1Department of Anatomy, Department of Human Science, Yamaguchi University School of Medicine, Ube 755-8505, Japan. toku@yamaguchi-u.ac.jp
Annals of the New York Academy of Sciences
|August 5, 2006
Summary
Pituitary adenylate cyclase-activating polypeptide receptor (PAC1-R) expression was studied in rat and rhesus monkey thymuses. TCDD exposure altered thymic structures and PAC1-R expression in rhesus monkeys.
Area of Science:
- Immunology
- Endocrinology
- Toxicology
Background:
- The pituitary adenylate cyclase-activating polypeptide receptor (PAC1-R) plays a role in various physiological processes.
- Investigating PAC1-R expression in the thymus is crucial for understanding immune system development and function.
Purpose of the Study:
- To investigate the expression of PAC1-R in the thymus of rats and rhesus monkeys.
- To examine the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on thymic structure and PAC1-R expression in rhesus monkeys.
Main Methods:
- Immunohistochemical analysis of PAC1-R expression in rat and rhesus monkey thymuses.
- Histopathological examination of thymic tissues from TCDD-exposed and control rhesus monkeys.
Main Results:
- PAC1-R positive cells were identified in the thymic medulla of both rats and rhesus monkeys.
- TCDD exposure led to unusual thymic structures in rhesus monkey dams (F0) and offspring (F1).
- Altered PAC1-R expression patterns were observed in the thymuses of TCDD-exposed rhesus monkeys compared to controls.
Conclusions:
- PAC1-R is expressed in the thymic medulla of rats and rhesus monkeys.
- TCDD exposure significantly impacts thymic morphology and PAC1-R expression in rhesus monkeys, suggesting potential immunotoxic effects.
