Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treatments in depression.

Fabrice Duval1, Barry D Lebowitz, Jean-Paul Macher

  • 1Centre Hospitalier, Rouffach, France. f.duval@ch-rouffach.fr

Dialogues in Clinical Neuroscience
|August 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypothalamic-pituitary-adrenal axis hyperactivity is normalized after successful intermittent theta-burst stimulation in resistant depressed patients.

Psychoneuroendocrinology·2024
Same author

Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia.

Healthcare (Basel, Switzerland)·2023
Same author

Hypothalamic-prolactin axis regulation in major depressed patients with suicidal behavior.

Psychoneuroendocrinology·2023
Same author

First-Dose Methylphenidate-Induced Changes in the Anti-Saccade Task Performance and Outcome in Adults with Attention-Deficit/Hyperactivity Disorder.

Psychiatric research and clinical practice·2022
Same author

Dopamine Function and Hypothalamic-Pituitary-Thyroid Axis Activity in Major Depressed Patients with Suicidal Behavior.

Brain sciences·2022
Same author

Posttraumatic Distress Symptoms and Their Response to Treatment in Adults With Prolonged Grief Disorder.

The Journal of clinical psychiatry·2021
Same journal

Mapping topological abnormalities in cortical similarity networks to schizophrenia-associated gene expression.

Dialogues in clinical neuroscience·2026
Same journal

Poor sleep quality correlates with axial symptoms and mood problems in Parkinson's disease.

Dialogues in clinical neuroscience·2026
Same journal

Treatment of posttraumatic stress disorder (PTSD).

Dialogues in clinical neuroscience·2026
Same journal

Comparisons of thalamocortical functional connectivity in transgender women and cisgender individuals: associations with cognition in a Chinese cohort.

Dialogues in clinical neuroscience·2026
Same journal

The Arabic Generalized Anxiety Disorder 2 (GAD-2): Psychometric evaluation among mothers of children with intellectual disabilities.

Dialogues in clinical neuroscience·2026
Same journal

Polarisation of brain dynamics in mania and depression.

Dialogues in clinical neuroscience·2026
See all related articles

Major depression involves multiple factors and worsens over time, necessitating early intervention. Treatment effectiveness varies, and ongoing research explores predictors and novel therapies for better outcomes.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Major depression is a multifactorial disorder influenced by genetics, personality, and life events.
  • Depression is a phasic illness where early stressor impact diminishes over time, suggesting progressive abnormalities.
  • Early intervention is crucial to prevent irreversible morphological and functional changes in the brain.

Purpose of the Study:

  • To review the current understanding of depression's pathophysiology and treatment.
  • To explore the effectiveness and predictors of various depression treatments.
  • To discuss strategies for treatment-resistant depression and emerging therapeutic concepts.

Main Methods:

  • Literature review of depression pathophysiology, treatment efficacy, and outcome predictors.

Related Experiment Videos

  • Analysis of clinical, neuroendocrine, polysomnographic, genetic, and neuroimaging data.
  • Discussion of therapeutic strategies for acute episodes and long-term management.

    • Main Results:

    • Depression is linked to progressive stress response abnormalities and impairments in plasticity.
    • Antidepressant efficacy may vary significantly between individuals despite statistical comparability.
    • Predictors of treatment outcome include clinical, biological, and genetic factors.

    Conclusions:

    • Early and adequate treatment of depression is vital to prevent long-term functional impairments.
    • Individualized treatment approaches are necessary due to variability in drug response and tolerability.
    • Continuous management and further research into novel therapies, like circadian rhythm regulation, are essential for optimal depression care.