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[Effectiveness of antihypertensive medications in patients with preeclampsia]

S Ivanov, M Mikhova

    Akusherstvo I Ginekologiia
    |August 8, 2006
    PubMed

    The presented study is retrospective and prospective in design. It is based on the medical records of Maternity hospital "Majchin dom" and planned studies during the period 1994-2005. 544 preeclamptic patients with singleton pregnancies were included. 334 (61.3%) of them were diagnosed with mild preeclampsia and 210 (38.7%) had severe preeclampsia. Blood pressure was monitored at least four times daily, depending on the severity of the case with mechanical manometer. In special cases cardiopulsometry was applied. In order to compare the effectiveness of different antihypertensive medications, administered orally, either alone, or in combination (no antihypertensive medication, Methyldopa, Nifedipin, beta-blockers and combinations between them), patients were divided in seven groups. The mean values of systolic and diastolic blood pressure, measured before delivery were compared. No statistically significant difference between the groups was noticed. We were not also able to find statistically significant difference in blood pressure measurements before delivery, between patients with severe preeclampsia, treated with parenteral Nepresol or Chlofazolin.

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