[Clinical experience with voluven solution used as a basic component for pump oxygenator filling during operations on...

Area of Science:

• Cardiovascular Surgery
• Anesthesiology
• Critical Care Medicine

Background:

• Extracorporeal circulation (ECC) requires fluid management for circuit filling.
• Different solutions like crystalloids, colloids (gelofusin), and hydroxyethyl starch (Voluven) are used.
• Clinical comparison of these solutions' effects during ECC is crucial.

Purpose of the Study:

• To comparatively analyze the clinical effects of Ringer's solution, gelofusin, and Voluven for ECC filling.
• To evaluate hematological, physicochemical, and biochemical parameters during ECC.
• To assess the efficacy of Voluven in patients undergoing valvular and coronary heart disease surgery.

Main Methods:

• Sixty-one patients undergoing ECC for valvular or coronary heart disease were divided into three groups based on filling solution.
• Blood samples were analyzed for hematological (blood cells, hemoglobin, free hemoglobin), physicochemical (blood gases), and biochemical (electrolytes, lactate) parameters.
• Hemodynamics, temperature, diuresis, and water balance were monitored during and after ECC.

Main Results:

• Voluven demonstrated a highly effective plasma-substituting effect.
• Beneficial properties of Voluven were noted, especially in prolonged ECC procedures for acquired heart diseases.
• Specific data on hematological, physicochemical, and biochemical changes across the three groups were detailed.

Conclusions:

• Voluven is a highly effective solution for extracorporeal circulatory circuit filling.
• Its efficacy is particularly advantageous in complex cardiac surgeries requiring extended extracorporeal support.
• The study supports the use of Voluven in managing fluid balance and patient physiology during ECC.