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Updated: Jul 8, 2026

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
Published on: May 31, 2011
The A-minor motifs in the decoding recognition process
1Institut de biologie moleculaire et cellulaire du CNRS, UPR 'Architecture et Réactivité de l'ARN', universite Louis-Pasteur, 15, rue R.-Descartes, 67084 Strasbourg, France.
Abstract:
The formation of A-minor motifs, mediated by adenines binding into the shallow/minor groove of stacked and helical Watson-Crick base pairs, is described. The conformations of the bacterial ribosomal decoding A site in various crystal structures are reviewed. The adenines A1492 and A1493 of the A site are seen either tucked in within the internal loop or bulging out and poised for interaction. This dynamic equilibrium contributes to the decoding process of the codon:anticodon base pairings. Aminoglycoside antibiotics lock the conformation of the A site in a single state with bulged-out adenines and thereby disrupt regulation of the decoding process.
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