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Related Concept Videos

Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

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Related Experiment Video

Updated: Jul 7, 2026

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
10:45

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

The interaction networks of structured RNAs.

A Lescoute1, E Westhof

  • 1Architecture et Réactivité de l'ARN, Université Louis Pasteur IBMC, CNRS, 15 rue R. Descartes, F-67084 Strasbourg, France.

Nucleic Acids Research
|December 1, 2006
PubMed
Summary

New diagrams visualize RNA base interactions, revealing conserved structural patterns and aiding network analysis of RNA folding. These tools map complex networks, highlighting relationships between helical domains.

Area of Science:

  • Structural Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Understanding RNA structure is crucial for deciphering its biological functions.
  • RNA molecules fold into complex three-dimensional structures stabilized by base-base interactions.
  • Existing visualization methods may not fully capture the intricate network of these interactions.

Purpose of the Study:

  • To develop novel planar diagrams for annotating pairwise base interactions in crystallized RNA molecules.
  • To map the complex networks of base-base interactions and relationships between helical domains.
  • To reveal conserved structural patterns and distances within RNA interaction networks.

Main Methods:

  • Annotation of all detectable pairwise base interactions from 3D crystallized RNA structures.

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Last Updated: Jul 7, 2026

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  • Creation of new planar diagrams to represent these interactions.
  • Analysis of diagrams to identify key relationships like co-axial stacking and base pairing (Watson-Crick and non-Watson-Crick).

    • Main Results:

    • The diagrams effectively map complex networks of base-base interactions.
    • Key relationships between helical domains, including stacking and bending, are clearly conveyed.
    • Structural similarities and conserved patterns/distances within RNA interaction networks are revealed, irrespective of function.

    Conclusions:

    • The developed diagrams offer a valuable tool for visualizing and analyzing RNA structural networks.
    • These visualizations can aid in understanding conserved motifs and structural similarities across diverse RNA molecules.
    • The diagrams provide a foundation for transforming RNA structures into graphs for network analysis.