Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What's so Bor(a)ing about Aurora-A activation?

Christiane Wiese1, Lori L O'Brien

  • 1Department of Biochemistry, University of Wisconsin, Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA.

Developmental Cell
|August 8, 2006
PubMed
Summary

Aurora Borealis (Bora) is identified as a key regulator of Aurora-A kinase activity. This finding advances our understanding of how Aurora-A is controlled during cell division, a crucial process for life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innovative Technologies for Kidney Research: Three-Dimensional Imaging and Quantification.

Seminars in nephrology·2025
Same author

Feature-driven whole-tissue imaging with subcellular resolution.

Cell reports methods·2025
Same author

Somites are a source of nephron progenitors in zebrafish.

Nature communications·2025
Same author

Altered renal vascular patterning reduces ischemic kidney injury and limits age-associated vascular loss.

American journal of physiology. Renal physiology·2025
Same author

Feature-Driven Whole-Tissue Imaging with Subcellular Resolution.

bioRxiv : the preprint server for biology·2025
Same author

Enhancing kidney organoid maturity with inducible vascularization: another step forward for in vitro modeling.

Kidney international·2024

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Aurora-A kinases are essential for cell division.
  • The precise regulation of Aurora-A activity remains poorly understood.
  • Conserved mechanisms controlling mitotic kinases are critical for cell cycle fidelity.

Purpose of the Study:

  • To identify key regulators of Aurora-A kinase activity during mitosis.
  • To elucidate the mechanisms controlling Aurora-A function in cell division.
  • To investigate the role of conserved proteins in mitotic regulation.

Main Methods:

  • Utilized genetic and biochemical approaches.
  • Investigated protein interactions and localization.
  • Performed functional assays in cell division models.

Main Results:

  • Identified the conserved protein Aurora Borealis (Bora) as a crucial regulator of Aurora-A.
  • Demonstrated that Bora controls Aurora-A activity during mitosis.
  • Provided new insights into the regulatory network of Aurora-A.

Conclusions:

  • Bora is a key component in the regulation of Aurora-A kinase.
  • Understanding Bora-Aurora-A interactions is vital for comprehending cell division control.
  • This discovery offers a new target for studying mitotic disorders.

Related Experiment Videos