Impaired innate immunity in Crohn's disease

The aetiology of Crohn's disease--a chronic intestinal disorder that involves an immune response against the commensal bacterial flora--remains fiercely debated. Two hypotheses exist: (i) those who think that the disease is caused by genetic defects that produce exaggerated innate responses to the flora, leading to excessive inflammation; and (ii) those who think that the genetic defects cause diminished inflammatory responses, in turn leading to uncontrolled accumulation of the inducer stimuli and, thus, activation of the adaptive immune system. Importantly, Marks and colleagues have recently investigated the immune response of Crohn's disease patients directly, convincingly showing impaired innate immunity.