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Undiagnosed dysglycaemia and inflammation in cardiovascular disease

O E Johansen1, K I Birkeland, E Brustad

  • 1Diabetic Out-Patient Clinic, Medical Department, Asker and Baerum Hospital, RUD, Oslo, Norway. odd.erik.johansen@broadpark.no

European Journal of Clinical Investigation
|August 9, 2006
PubMed

Insights

Undiagnosed dysglycaemia (high blood glucose) is common in patients with cardiovascular disease, affecting nearly half of those with coronary artery disease. Inflammation levels correlate with blood glucose, highlighting a link between glucose metabolism and vascular complications.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Cardiovascular disease is linked to elevated glucose, but dysglycaemia prevalence in these conditions is unclear.
  • This study investigates unknown dysglycaemia and inflammation in Caucasian patients with ischaemic vascular complications.

Purpose of the Study:

  • To determine the prevalence of undiagnosed dysglycaemia (impaired fasting glycaemia, impaired glucose tolerance, or diabetes mellitus) in patients with coronary artery disease (CAD), cerebrovascular disease (CVD), and peripheral artery disease (PAD).
  • To examine the association between dysglycaemia and inflammatory markers in these patient groups.

Main Methods:

  • A case-controlled study involving 149 patients with CAD, PAD, or CVD and 59 healthy controls.
  • Dysglycaemia was assessed using a 75-g oral glucose tolerance test based on WHO/ADA criteria.
  • Fasting blood samples were analyzed for inflammatory parameters.

Main Results:

  • Dysglycaemia prevalence was significantly higher in patients (49% CAD, 55% CVD, 57% PAD) compared to controls (29%).
  • Odds ratios for dysglycaemia were elevated for CAD (1.7), CVD (1.9), and PAD (2.0).
  • Inflammatory markers were elevated in patient groups and increased with higher blood glucose levels; specific anti-inflammatory markers were reduced.

Conclusions:

  • Undiagnosed dysglycaemia is prevalent across different ischaemic cardiovascular manifestations.
  • A dose-dependent relationship exists between inflammation and glucose levels in patients with cardiovascular disease.
Abstract

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